Showing posts with label Gastric. Show all posts
Showing posts with label Gastric. Show all posts

Saturday, April 2, 2022

Probiotics and mental health: Dahi, idli, pickle good for your mood and brain function

 Website content extracted from: Probiotics and mental health: Dahi, idli, pickle good for your mood and brain function | Health Tips and News (timesnownews.com)

Updated Sep 17, 2021 | 23:46 IST

Who would have thought that the brain's health is directly affected by the balanced of gut microbiota? No wonder our ancestors traditionally wove in fermented foods and probiotics like dahi etc in our diet.

Gut brain connection
Gut brain connection  |  Photo Credit: iStock Images

KEY HIGHLIGHTS

  • The body is like a matrix. Everything is connected. But did you know that your brain and gut have a different connection?
  • There is not just you and your brain and gut but millions of microbes - the friendly microbiota from your guts that can make or break your mental health.

Harvard research shows that probiotics can do more than improve your gut health. They also may indirectly enhance your brain health and functions.

Probiotics are traditionally thought to improve digestive health, and they are often used to treat diarrhoea or bloating. According to Johns Hopkins Medicine, probiotics have some basic functions we already know about: 
•    Shaping the body’s immune system
•    Producing antimicrobial substances
•    Fermenting fibre in the diet to generate nutrients for the cells that line our intestines

Patients suffering from depression experience significant mood, anxiety, and cognitive symptoms. Currently, most antidepressants work by altering neurotransmitter activity in the brain to improve these symptoms. Now research shows that the gut and brain are connected, a partnership called the gut-brain axis. Harvard says the two are linked through biochemical signalling between the nervous system in the digestive tract, called the enteric nervous system, and the central nervous system, which includes the brain.

The Vagus nerve complex:
The primary information connection between the brain and gut is the vagus nerve, the longest nerve in the body. 
Vagus nerve, also called X cranial nerve or 10th cranial nerve is the longest and most complex of the cranial nerves. The vagus nerve runs from the brain through the face and thorax to the abdomen. It is a mixed nerve that contains parasympathetic fibres.
The gut has been called a "second brain" because it produces many of the same neurotransmitters as the brain does, like serotonin, dopamine, and gamma-aminobutyric acid, all of which play a key role in regulating mood. In fact, it is estimated that 90 per cent of serotonin is made in the digestive tract.

Brain and gut are interconnected:
According to the Harvard report, what affects the gut often affects the brain and vice versa. When your brain senses trouble—the fight-or-flight response—it sends warning signals to the gut, which is why stressful events can cause digestive problems like a nervous or upset stomach. On the flip side, flares of gastrointestinal issues like irritable bowel syndrome (IBS), Crohn's disease, or chronic constipation may trigger anxiety or depression.


The gut bacteria sent satiation signals too:
The brain-gut axis works in other ways, too. For example, just like your gut sends signals of hunger through the digestive tract’s various mechanisms that the brain reads, your gut helps regulate appetite by telling the brain when it is time to stop eating. About 20 minutes after you eat, gut microbes produce proteins that can suppress appetite, which coincides with the time it often takes people to begin feeling full. That is how when your gut flora is fine, you are less likely to overeat.

Role of probiotics in the gut-brain axis:
Scientists have been studying the gut-brain axis and the interactions between enteric microbiota, central and enteric nervous systems. They have researched how probiotics might fit in the gut-brain axis? Some research has found that probiotics may help boost mood and cognitive function and lower stress and anxiety. 

For example, a study published online on 10th November 2016, by Frontiers in Aging Neuroscience found that Alzheimer's patients who took milk made with four probiotic bacteria species for 12 weeks scored better on a test to measure cognitive impairment compared with those who drank regular milk.

A small 2013 study reported in the journal Gastroenterology found that women who ate yoghurt with a mix of probiotics, twice a day for four weeks, were calmer when exposed to images of angry and frightened faces compared with a control group. 

MRIs also found that the yoghurt group had lower activity in the insula, the brain area that processes internal body sensations like those emanating from the gut.

After thorough research done in Italy, doctors claim that strong evidence suggests that gut microbiota has an important role in bidirectional interactions between the gut and the nervous system. It interacts with CNS by regulating brain chemistry and influencing neuro-endocrine systems associated with stress response, anxiety and memory function. It's too early to determine the exact role probiotics play in the gut-brain axis since this research is still ongoing. Probiotics may not only support a healthier gut but a healthier brain, too.

Foods that contain probiotic factors:
Now, probiotics are not just the ‘good bacteria’ preparations sold by commercial outlets. The friendly bacteria flora is also present in other traditional Indian foods like idli, dosa, pickles, Dahi, kefir, etc.

Disclaimer: Tips and suggestions mentioned in the article are for general information purposes only and should not be construed as professional medical advice. Always consult your doctor or a professional healthcare provider if you have any specific questions about any medical matter.

Wednesday, March 23, 2022

Human Gut Bacteria Could Be Accumulating Our Medications Without Us Realizing

 Website content extracted from: Human Gut Bacteria Could Be Accumulating Our Medications Without Us Realizing (sciencealert.com)

13 SEPTEMBER 2021



When we take medicine, there are often unintended consequences. In the most common scenarios, these are known as side effects.

But 'side effects' don't begin to encompass the multitude of strange things that can happen when various compounds enter our system.

Sometimes, these unintended consequences occur after drugs physically exit the body, with medicine finding a second life in animals accidentally exposed to the formulations downstream.

Yet even before drugs have a chance to leave your body, they most likely will also interact with organisms other than just you, such as the gut microbiome.

In a new study, scientists found that numerous species of bacteria that live in the human gut can interact with and accumulate a number of different types of medicines taken by people, including antidepressants, pain relief, heart medication, and more.

"This calls for us to start treating the microbiome as one of our organs," says one of the study authors, bioinformatician Peer Bork from the European Molecular Biology Laboratory (EMBL) in Germany.

Scientists already knew that bacteria in the human microbiome had the ability to chemically modify drugs that they come into contact with inside the body – a phenomenon called biotransformation.

But the new research shows that biotransformation isn't the whole side of the story.

Experiments in the lab with over 20 species of human gut bacteria exposed to 15 different kinds of human-targeted drugs showed that, most of the time, bacteria ended up unexpectedly accumulating the chemicals without actually modifying them.

"It was surprising that the majority of the new interactions we saw between bacteria and drugs were the drugs accumulating in the bacteria," says Kiran Patil, director of research at the MRC Toxicology Unit at the University of Cambridge.

"Until now, biotransformation was thought to be the main way that bacteria affect the availability of drugs to the body."

The distinction could be important. According to the researchers, bioaccumulated drugs show the potential not only to alter bacterial behavior and metabolic processes, but to affect the distribution and balance of bacterial populations.

In other words, therapeutic drugs don't just affect you – they're likely having unknown effects on the gut microbiome and its overall composition, if these experimental results are indeed replicated in actual human patients, which isn't yet known.

From the sounds of it, though, every individual gut's mileage will vary.

"These will likely be very personal differences between individuals, depending on the composition of their gut microbiota," Patil says. "We saw differences even between different strains of the same species of bacteria."

Aside from the issue of what medication might be doing to bacteria, however, there's also something else to consider.

The researchers say the medications people take might be rendered less effective by bacterial hijacking of their chemical ingredients.

After all, when we measure dosage, we haven't exactly been accounting for the hangers-on: a microbial entourage who ends up accumulating a certain amount of what we swallow.

In addition to potentially reducing the effectiveness of some medications, it's possible the same phenomenon could also introduce or affect side effects in patients, the researchers say, with drug regimens being slightly altered by invisible hands.

A lot more research will be needed to understand just how significant this bacterial accumulation issue really is, and there's no time like the present.

"The next steps for us will be to to take forward this basic molecular research and investigate how an individual's gut bacteria tie with the differing individual responses to drugs such as antidepressants – differences in whether you respond, the drug dose needed, and side effects like weight gain," Patil says.

"If we can characterize how people respond depending on the composition of their microbiome, then drug treatments could be individualized."

Until such time, don't forget to bring enough for everyone.

The findings are reported in Nature.

Tuesday, March 22, 2022

How To Get More Prevotella Bacteria?

 Website content extracted from: How To Get More Prevotella Bacteria? – iLoveMyCarbonDioxide

March 2, 2022

Monday is a good day to go vegetarian. There have been many studies linking high-quality diets rich in fruits and vegetables and low in meat to increased diversity of microbiota, especially Prevotella, and high levels of good bacteria. The consumption of meat-dense food may stimulate greater activity and abundance of microorganisms linked to inflammatory bowel disease on a meat-heavy diet.

How Do You Get Prevotella Bacteria?

Gram-negative bacteria that are part of the Prevotella family include Pseudomonas aeruginosa, Serratinia, and Serratinia reit. spp. are the most common types of parasite. Inflammatory respiratory tract infections, including aspiration pneumonia, lung abscesses, pulmonary empyema, and chronic otitis media, are responsible for the colonization of these tissues. It is characterized by a thick layer of mucus at the back of the mouth and between the nasal muscles.

Where Do You Get Prevotella?

Usually found in crevices of the gums, Prevotella oralis grows within the biofilm of healthy bacteria, but often causes infections in rare cases.

Where Can I Buy Prevotella Bacteria?

According to recently published research4, antibacterial Prevotella species typically colonize mucosal sites; they’re among the oldest genus found in the respiratory system4, 5 and a central component for three important gut bacteria in its main enterotype.

How Do You Get More Bacteria?

  • Have a good diet, don’t waste your money!…
  • Avoid processed foods and stop drinking sugar.
  • It is gut probiotics that help keep you healthy.
  • Don’t use antibiotics…
  • Take on prebiotics in healthy ways…
  • Natural Fermentation Foods are gut friendly…
  • …If you are going to eat red meat, cut back.
  • There’s nothing time for ates past your bedtime!
  • What Does Prevotella Feed On?

    It has been associated with high plant carbohydrate content, such as fruit and vegetables (in which it scores very high on carbohydrates) and a high fat intake. As antagonistic animals, Bacteroides and Prevotella live in distinct habitats within the humans.

    How Is Prevotella Transmitted?

    The Prevotella spp family is a group of plants. A abscesses of the lung, abdomen, or brain can result from such situations. Dental, lower abdomen, and wound infections are also possible as a result of the bacteria. In the course of transmission, infected individuals may receive care from an indirect source.

    Is Prevotella A Good Bacteria?

    It has been hypothesized that Prevotella belongs to a plant-based diet; however it is also linked to chronic inflammatory conditions, such as arthritis, mucosal problems and T-cell maturation when HIV-1 is infected.

    How Do You Get More Prevotella Bacteria?

    The benefits of a high-nutrient, low-meat diet include a higher-than-average amount of bacterial diversity in the gut and Prevotella immunity. According to expert testimony, increasing amounts and activity of microorganisms that contribute to inflammation of the bowel may occur when you dine on meat too often.

    What Does Prevotella Do In The Gut?

    Polysaccharide breakdown is a hallmark of a dominant colonizer of agrarian systems. As a result of gut commensal Prevotella bacteria, their content is highly dependent on yeast. On the other hand, studies suggest the presence of Prevotella species in intestinal pathonobits may be beneficial.

    What Foods Increase Bacteria?

  • A great source of healthy friendly bacteria (known collectively as probiotics) is yoghurt.
  • Dairy products like kefir go through fermentation to produce this yoghurt drink. It contains a high concentration of probiotics.
  • The Miso hee,… is a strong one, regardless of how bad hee.
  • It comes in a variety of flavors…
  • A kimchi treat…..
  • An item that goes by the name of sourdough.
  • There are millions of almonds in the world…
  • The oil of olive trees.
  • What Is The Fastest Way To Increase Good Bacteria?

  • Get back to regular stress levels. When you experience chronic high levels of stress, your whole body, including your digestive tract, suffers.
  • Don’t get hungover after you get enough sleep.
  • Get plenty of sleep… Eat slowly…
  • Drink plenty of water. Stay hydrated.
  • Inflammation or probiotics can be taken in moderation.
  • Eat a small amount of protein-containing food before you become ill..
  • Create a diet that works for you.
  • What Food Is Highest In Probiotics?

  • A healthy immune system is fueled by probiotics found in yogurt. Yogurt helps control inflammation, and boosts the body’s own probiotics.
  • Drinking kefir. Kefir is a fermented probiotic milk drink.
  • Pickled cabbage made from finely shredded bacteria found in lactic acid….
  • My word is “teech”, which means…
  • It’s been around forever and a day that I got kimchi…
  • I was given Miso as a gift…
  • A drink made from kombucha.
  • Pickles.
  • What Are The Top 5 Probiotic Foods?

  • One of the most popular probiotics food is greek yogurt, a tangy-tasting yogurt made from the milk of goats, sheep or cows.
  • Associated Vegetables (cultured andfermented)…
  • …and organic produce such as kombucha are abundant…
  • A miso meal. I’m pretty sure you want my help…
  • Apple cider vinegar is a popular alcoholic beverage.
  • Watch Why Do Antibiotics Work On Bacteria Video

    The Power Of Postbiotics: What They Are & How They Support Our Overall Health

     Website content extracted from: Postbiotics: What They Are & How They Support Our Health (mindbodygreen.com)

    The link between the gut microbiome and overall human health is a hot area of scientific research, which is why you're likely familiar with prebiotics and probiotics. But I'd be willing to wager you haven't paid much attention to the "biotics" that may matter the most: postbiotics.

    What is a postbiotic?

    While the scientific community is still debating the exact definition of postbiotics, broadly speaking, the term refers to compounds resulting from the microorganisms in our gut.

    Our gut microbiome consists of bacteria, yeast, fungi, viruses, and archaea, which thrive in this nutrient-rich environment. These organisms metabolize and convert properties from the food we eat into active substances (postbiotics) that have a health benefit for the host.

    A challenge with these substances is that even after taking pre- and probiotics, many people don't have the right microbiome to produce optimal amounts of postbiotics, which is why supplementation is emerging as a unique solution.

    There are several different postbiotic compounds that have already been identified. These include short-chain fatty acids (SCFAs), vitamins, polysaccharides, proteins, and lipids—each exerting its own beneficial effect. While researchers are still discovering the many ways postbiotics affect our health, the following have been well studied with promising results demonstrating their benefits.

    ADVERTISEMENT

    Postbiotics & their effect on human health:

    Urolithin A for mitochondrial health

    Mitochondria are the powerhouses inside our cells, generating most of the energy we need to function. Over time, oxidative stress and age contribute to the decline in mitochondrial function, and our health suffers as a result.

    Urolithin A is the first postbiotic shown to activate an essential repair process called mitophagy, where damaged mitochondria are cleared away and renewed. A recent study at the University of Washington School of Medicine in Seattle showed that supplementing with a pure form of Urolithin A improved mitochondrial function and also improved hand and leg muscle endurance in older adults when compared to placebo.

    While Urolithin A is a naturally occurring postbiotic derived from the polyphenolic compounds in pomegranates, nuts, and berries, an earlier study showed that only 30% to 40% of people are able to convert these compounds into enough levels of Urolithin A. This is likely due to the highly personalized nature of the gut microbiome. On average, the supplement provided people with six more Urolithin A than a glass of pomegranate juice—hence the emerging interest in supplementing with a pure form of this postbiotic.

    Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population.

    Butyrate for improved digestion

    Short-chain fatty acids, including butyrate, propionate, and acetate, are produced by fiber fermentation in the colon. They are an important source of energy for the cells of the digestive tract and therefore play a crucial role in the turnover and renewal of the intestinal lining.

    These postbiotics may help preserve the integrity of the intestinal barrier, making them helpful in treating inflammatory bowel disease and other digestive disorders. Additionally, SCFAs are being studied for their use in preventing cancer growth, supporting healthy blood sugar levels, and modulating immune function.

    Equol for postmenopausal health

    Equol is a postbiotic that has shown promise in supporting women's postmenopausal health. A small study demonstrated that intestinal bacteria could convert an isoflavone found in soybeans into equol, a postbiotic compound with a similar structure to estrogen. The study found that equol functioned like a weak alternative to estrogen and was able to help reduce the number and severity of hot flashes in peri- and postmenopausal women.

    However, studies from early in the 2010s showed that only 30 to 60% of the Japanese population could convert soy isoflavones to equol and therefore were not able to get the health benefits associated with this postbiotic. Just like with Urolithin A, this may need to be taken as a supplement in order to get maximal benefit.

    Beta-glucans for immune support

    Some types of postbiotics appear to interact with the cells of the immune system. Specifically, beta-glucans (β-glucans) may support the cellular response to pathogens like parasites, bacteria, and viruses.

    Beta-glucans are a polysaccharide structural component of the cell wall of fungi, yeast, and some bacteria. They also are found in cereals such as oats and barley. These compounds are detected by receptors in the intestines and stimulate an immunologic response. Studies have shown that beta-glucans can modulate the activity of immune cells, activating their antimicrobial activity. They also support health by increasing the absorption of carotenoids, antioxidants with anti-inflammatory properties, and promoting the adherence of healthy bacteria to the gut lining. These immune modulators are being studied for their use as a treatment for several immune-related conditions.

    Bottom line.

    Postbiotics are the next frontier of understanding the gut microbiome. As research continues to unfold, postbiotic therapy is likely to become an important tool in treating a wide variety of health conditions, from improving immunity to promoting healthy aging.

    Monday, March 21, 2022

    How the Ecosystems in Our Guts Could Be Linked to Brain Disorders

     Website content extracted from: How Gut Microbiome Could Be Linked to Brain Disorders like Alzheimer's (gizmodo.com)


    By

    Within our guts is a tiny ecosystem populated by trillions of microorganisms. These germs affect digestion, the immune system, and even brain functioning. Scientists have also started investigating the potential role of gut bacteria in psychiatric and neurological conditions, including neurodegenerative diseases like Alzheimer’s and Parkinson’s. If gut microbes prove influential, this could reveal how these diseases work, leading to earlier detection and new treatment targets.

    Neurodegenerative diseases progressively damage and kill nerve cells, causing problems with mental or movement function, and sometimes both. Over the past 30 years, these diseases have grown more common with the world’s increasingly older population, yet there are no cures and few effective treatments. Alzheimer’s and Parkinson’s diseases lead the way, affecting millions of people worldwide.

    These diseases arise from combinations of genetic, environmental, age-related, and lifestyle factors, but in most cases, doctors can’t pinpoint a cause. Given that the brain connects with the gut, scientists are increasingly looking at the possible role of gut microbes.

    Much of this research has focused on Parkinson’s, which is associated with gastrointestinal issues. But preliminary connections between the gut microbiome and other neurodegenerative diseases, like Alzheimer’s and amyotrophic lateral sclerosis (ALS), are also emerging.

    Bacteria account for the majority of the microorganisms in our guts, and they’re in direct and indirect communication with the nervous system, which controls mental functions, movement, sensory perception, and automatic processes like breathing.

    Through a two-way connection called the gut-brain axis, our microbes could be liaising with the brain via nerves and chemical pathways. For example, gut bacteria can synthesize neurotransmitters, the brain’s molecular messengers, and other chemicals used in the brain. When absorbed by the gut walls and into the bloodstream, these molecules can travel to the brain. The bacteria also interact with immune cells. This could indirectly affect the brain through immune cell signaling pathways, or, in late neurodegenerative disease stages, directly affect the brain. During the late disease stages, it’s possible that immune cells infiltrate the brain from the bloodstream, through more porous blood vessels.

    The role of gut bacteria in neurodegenerative diseases is still an emerging field of research. “There’s some rightful skepticism,” said Timothy Sampson, assistant professor of physiology at Emory University.

    “It is still a relatively young field, so there are a lot of unknowns,” said Jan-Pieter Konsman, a neuroimmunologist at the University of Bordeaux. Until recently, studies of the gut microbiome and neurodegenerative diseases were limited to comparing microbial communities in people with and without the diseases. Most studies didn’t look deeper at the operations within those ecosystems.

    “You’ve got to break down that community to understand those interactions,” said Maureen O’Malley, a philosophy of microbiology researcher at the University of Sydney. But in the past five years, groups are increasingly drilling into those interactions, studying which specific microbes and molecules could be involved in disease.

    Parkinson’s disease, in particular, has captured the attention of researchers interested in the gut-brain axis. Gastrointestinal issues, like constipation, often occur in people years before they develop the movement-related symptoms characteristic of the disease.

    “One of the cardinal features originally of James Parkinson’s diagnosis of ‘the shaking palsy,’ which has become Parkinson’s disease, was this observation of intractable constipation in patients,” said Lynne Barker, associate professor of cognitive neuroscience at Sheffield Hallam University. The fact that the gut is involved in Parkinson’s hasn’t been a secret.

    Scientists look at bacterial genes in stool samples to approximate the bacterial composition of the gut. These studies have shown that microbiomes of people with Parkinson’s differ from those without Parkinson’s. These differences arise independently of other influences over the microbiome, like diet. “But that leads to this big chicken-and-the-egg problem,” said Sampson. “Did the disease cause the microbiome to change, or did the change in the microbiome influence the disease?”

    In a small, preliminary study, Purna Kashyap, professor of medicine and physiology and co-director of the microbiome program at Mayo Clinic, and his team used mouse models of Parkinson’s disease and showed that mice needed gut bacteria to develop movement-related symptoms. In germ-free mice, ones without any detectable bacteria, fungi or viruses in or on their bodies, movement problems never materialized.

    Studies in rats and mice have also shown that the gut bacteria Escherichia coli make proteins akin to alpha-synuclein protein clumps that form in the brain in Parkinson’s disease. In mice engineered to overexpress alpha-synuclein, Sampson has shown that this bacterial protein in the gut exacerbates both alpha-synuclein aggregation in the brain and movement symptoms.

    O’Malley cautioned that while these animal experiments go deeper than earlier studies, they should be interpreted with caution, since animal studies often fail to replicate in humans. But, she said, “I think you can still get some of the suggestive findings that then allow you to build a better model of what’s going on.”

    More recently, a few research groups have started looking for gut microbiome disturbances in other neurodegenerative diseases, like Alzheimer’s. Protein clumps called beta-amyloid plaques disrupt brain cell functions in people with Alzheimer’s. Mouse models of Alzheimer’s disease also suggest a role for gut microbes.

    “If you keep those mice germ-free, they don’t develop as many amyloid plaques,” said Barbara Bendlin, a professor of medicine at the University of Wisconsin, Madison. “It does really suggest that in some way there’s a link between microbes and the development of Alzheimer’s disease pathology.”

    As a starting point in human research, Bendlin and her team have studied gut microbiomes of people with Alzheimer’s disease by analyzing stool samples. In a small study of 25 people with Alzheimer’s and 25 people without, they found that Alzheimer’s patients had a less diverse bacterial population and different amounts of certain bacteria. They also analyzed the cerebrospinal fluid, which surrounds the brain and spinal cord, of participants to look for relationships between Alzheimer’s-related biomarkers and the gut microbiome.

    “We found that there were relationships between the gut microbiome and those cerebrospinal fluid biomarkers, even among individuals who were asymptomatic,” said Bendlin. “That suggested to us that maybe there’s a link between the gut and brain pathology that’s present even before people develop dementia.”

    Scientists have also begun exploring links between gut bacteria and ALS, a disease in which neurons powering the muscles gradually die. In a study of mice with a genetic mutation known to cause ALS in some human cases, Eran Blacher, postdoctoral fellow studying the gut-brain axis at the neurology department of Stanford University School of Medicine, and his team showed that gut microbiome changes preceded ALS symptoms. Blacher said that indicated that such changes might have to do with the disease.

    The researchers also found that certain gut bacteria produced molecules that altered the disease in mice. Giving the mice a probiotic supplement with that bacteria boosted levels of the molecule nicotinamide and improved their symptoms. Nicotinamide produces key chemicals for cellular pathways scientists think are involved in ALS. “So we can change the disease progression and manifestation by treating the mice with specific bacteria, which was very surprising,” said Blacher.

    Blacher’s preliminary findings in a small group of human patients supported those results: People with ALS had lower levels of bacterial genes needed for nicotinamide metabolism in their stool samples compared to people without ALS. They also had lower levels of nicotinamide in their blood and cerebrospinal fluid. “We are not saying that we were able to cure ALS, or to change anything in disease progression in humans,” said Blacher. Rather, larger follow-up studies could reveal more about mechanisms underlying ALS and reveal potential therapy targets.

    But overall, the microbiome’s role in neurodegenerative diseases remains mysterious. Barker’s group is analyzing data from a small feasibility study to see whether administering a common probiotic to people with Parkinson’s disease could change their microbiome composition or influence quality of life. Unlike earlier work, Barker said her group is looking beyond big-picture changes in microbial communities to zero in on specific bacterial species.

    Still, studies are far from revealing microbiome-based treatments for neurodegenerative diseases. Even if some kind of probiotics or dietary changes were shown to be effective at alleviating some symptoms, it wouldn’t be a cure for these complicated diseases. If gut microbes are involved in neurodegeneration, scientists also need to figure out how this fits with other potential disease causes.

    “We have not learned the mechanisms that link that to the brain, and until we firmly know those, we’re not going to be able to develop effective treatments,” said Bendlin.

    Jackie Rocheleau is a freelance journalist and editor based in upstate New York. She writes about neuroscience, public health, and medicine. Follow her on Twitter at @JackieRocheleau.

    Tea for fresh breath

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