Showing posts with label Heart. Show all posts
Showing posts with label Heart. Show all posts

Thursday, March 24, 2022

Sleeping with a light on may be bad for your heart and blood sugar

 Website content extracted from: Sleeping with a light on may be bad for your heart and blood sugar | Live Science

woman sleeping in bed with TV and bedside lamp on
(Image credit: Steve Prezant via Getty Images)

One night spent sleeping in a moderately lit room, rather than a dimly lit room, can lead to higher heart rate during the night and insulin resistance the next morning, a small study suggests. 

The study included two groups of 10 healthy adults. One group slept in dimly lit rooms for two consecutive nights and the other slept in dimly lit rooms one night and then moderately lit rooms the next, according to the study, published March 14 in the journal Proceedings of the National Academy of Sciences. The moderately lit rooms were illuminated with a 100 lux overhead light, which is about as bright as it would be on an overcast day, according to The Washington Post

A 100 lux light could also be compared to a lit television screen in a darkened room or a street light shining through a thinly veiled window, New Scientist reported

All the study participants wore heart monitors to sleep, and on the second night, the group that slept in moderately lit rooms showed a marked increase in heart rate while they slept, as compared to the night before, the researchers observed. The group that slept in dim lighting both nights showed no significant change.

Related: 5 surprising sleep discoveries

"We showed your heart rate increases when you sleep in a moderately lit room," Dr. Daniela Grimaldi, a co-first author and research assistant professor of neurology at Northwestern University, said in a statement. "Even though you are asleep, your autonomic nervous system is activated." The autonomic nervous system regulates involuntary bodily processes, such as breathing, heart rate, pupil dilation and digestion, as well as the fight-or-flight response. 

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If the autonomic nervous system is driving up heart rate during the night, "that’s bad," Grimaldi said. "Usually, your heart rate together with other cardiovascular parameters are lower at night and higher during the day." 

The study authors also ran several tests to estimate the participants' insulin resistance each morning of the study, after they awoke. The hormone insulin normally helps cells take in glucose, or sugar, from the bloodstream. But when cells are resistant to insulin, they don't take in glucose as readily, and the body produces more and more insulin to compensate. Over time, cells become resistant to even these sky-high insulin levels, which causes blood sugar levels to soar. 

On the first morning, after they'd slept in dimly lit rooms, both study groups scored about the same on the insulin resistance tests. These tests included the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), a calculation that takes fasting insulin and blood sugar levels into account, as well as direct tests of how the body responds to glucose, called an oral glucose tolerance test (OGTT) and the Matsuda insulin sensitivity index.

On the second morning, the group that slept in the moderately lit room scored worse on these tests, while the group that slept in dim light scored about the same or better as the day before. "Exposure to a single night of [moderate] room light … during sleep increased measures of insulin resistance the next morning," the researchers wrote in their report.

This study is limited in that it only included 20 people and only monitored the participants for two days and nights. People shouldn't assume that they need to change their sleeping habits unless these results are borne out in a larger trial, Jim Horne, a U.K.-based neuroscientist specializing in the study of sleep, told New Scientist. 

Originally published on Live Science. 

Study: Medium chain fatty acid can someday help in treating heart attacks

 Website content extracted from: Study: Medium chain fatty acid can someday help in treating heart attacks | Health - Hindustan Times

"Heart attacks are still a leading cause of death worldwide, that often come with devastating complications," said Zhong Wang, Ph.D., an associate professor of cardiac surgery at the University of Michigan Frankel Cardiovascular Center, who is the senior author of the study.

Published on Mar 11, 2022 09:53 PM IST

ANI | , Washington

A medium-chain fatty acid found in energy drinks might one-day help protect against heart attack injuries, suggests a recent study by researchers at the University of Michigan Frankel Cardiovascular Center.

The preclinical study was published in 'eLife'.

"Heart attacks are still a leading cause of death worldwide, that often come with devastating complications," said Zhong Wang, Ph.D., an associate professor of cardiac surgery at the University of Michigan Frankel Cardiovascular Center, who is the senior author of the study.

ALSO READ: Heart attack plus cardiac arrest survivors at higher risk of early death: Study

He added, "Better options are needed to reduce injury to the heart after a heart attack, and even improve heart function. In this publication, we target the interplay between energy metabolism and epigenetics mediated by the medium-chain fatty acid 8C."

Wang and colleagues were able to protect against heart attack injury in rat models with octanoic acid, an eight carbon (8C) medium-chain fatty acid, as well as a few other metabolites. Those fatty acids produced acetyl-CoA, a building block for energy metabolism, which a stressed heart desperately needs.

The idea is that a physician would administer this therapy to a person once they arrive at the hospital after having a heart attack, to reduce further injury and improve heart function during recovery, he says.

"Understanding the crosstalk between energy metabolism and epigenetics may not only provide an effective target for myocardial infarction, but also have broad implications in other ischemic injury-caused organ damage beyond cardiac diseases," said Ienglam Lei, Ph.D., from the Frankel CVC's Department of Cardiac Surgery and the University of Macau in China, who conducted the study's key experiments.

Wang says the next step would be to test this molecule in large animal models, followed by clinical trials. The research team has been studying the epigenetic regulation of heart attack for more than 10 years.

This story has been published from a wire agency feed without modifications to the text.

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